Unit 5a

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Unformatted text preview: dial Infarction If early enough, might treat with thrombolytics or with angioplasty/bypass surgery. Drugs Treating Angina Drugs • Nitrates and nitrites – Nitroglycerine - a nitrate, is drug of choice • β blockers (Propranolol, nadolol) – does not help during attack – used to prevent attack (decrease workload of heart) Drugs Treating Angina Drugs • Calcium channel blocking agents (verapamil, nifedipine, diltiazem, nicardipine, nimodipine) – Mechanism: Blocks extracellular calcium into cells Shockwave Flash Object • Dilation of coronary and peripheral vessels • Decrease in cardiac contractility – Useful chiefly in Prinzmetal’s "variant" angina due to coronary artery spasm – Not better than nitrates – Not very useful if coronary vessels are occluded. – Side effects: From relaxation of smooth and cardiac muscle. • • • • Hypotension, peripheral edema Dizziness, headache Bradycardia and possible CHF if patient susceptible Constipation, nausea, diarrhea, fatigue. Drugs Treating Angina Drugs • Dipyridamole (Persantine®) – Not for acute attacks. – Causes selective vasodilation of coronary arteries. – Seems to reduce nitrate requirements in some patients. – Adverse effects minimal and transient • Headache • Nausea, GI distress – Not very popular as an antianginal agent but being used as an anticoagulant due to its inhibition of platelet aggregation. Nitroglycerine: Relaxes Smooth Muscle Nitroglycerine: Decreasing Workload of Heart –Slight increase O2 Supply 2 • Routes of Administration – Sublingually (must bypa...
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This document was uploaded on 02/07/2014.

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