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Unformatted text preview: dial Infarction If early enough, might treat with
thrombolytics or with
angioplasty/bypass surgery. Drugs Treating Angina
• Nitrates and nitrites
– Nitroglycerine - a nitrate, is drug of choice • β blockers (Propranolol, nadolol)
– does not help during attack
– used to prevent attack (decrease workload of
heart) Drugs Treating Angina
• Calcium channel blocking agents (verapamil, nifedipine,
diltiazem, nicardipine, nimodipine)
– Mechanism: Blocks extracellular calcium into cells Shockwave Flash
Object • Dilation of coronary and peripheral vessels
• Decrease in cardiac contractility
– Useful chiefly in Prinzmetal’s "variant" angina due to coronary artery spasm
– Not better than nitrates
– Not very useful if coronary vessels are occluded. – Side effects: From relaxation of smooth and cardiac muscle.
• Hypotension, peripheral edema
Bradycardia and possible CHF if patient susceptible
Constipation, nausea, diarrhea, fatigue. Drugs Treating Angina
• Dipyridamole (Persantine®)
– Not for acute attacks.
– Causes selective vasodilation of coronary arteries.
– Seems to reduce nitrate requirements in some
– Adverse effects minimal and transient
• Nausea, GI distress
– Not very popular as an antianginal agent but being used as an
anticoagulant due to its inhibition of platelet aggregation. Nitroglycerine: Relaxes Smooth Muscle
Decreasing Workload of Heart –Slight increase O2 Supply
2 • Routes of Administration
– Sublingually (must bypa...
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This document was uploaded on 02/07/2014.
- Spring '14