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Unformatted text preview: bound) - may cause hemorrhage
– Special caution: Any drug that binds to plasma proteins.
Interactions often occur. Normal Clot Resolution
Activate Plasminogen Plasminogen
Acts as Enzyme Breaks Fibrin and Fibrinogen
Produces Products that Inhibit Coagulation Thrombolytic:
streptokinase, urokinase, anistreplase, recombinant tissue plasminogen activator (rTPA)
streptokinase, urokinase, anistreplase, recombinant tissue plasminogen activator (rTPA) • Therapeutic Uses:
– Acute pulmonary embolism
Deep venous thrombosis
Arterial clots • Contraindications:
– Active bleeding tendencies
– Cerebrovascular accident 2 hours old or more (approximately)
– Tumor • Cautions:
– Surgery or childbirth in the lasts few months
– Watch for bleeding tendencies
– Anaphylactic reactions possible Antilipemic Agents
• Controversial drugs
– most have severe side effects
– overall unproven usefulness, general population...
• do lower heart attack/stroke risk but…
• cause other problems • Study June 1987 –
– atherosclerosis can be reversed in less than 1/4 of the
population • Cholesterol is associated with heart disease.
• Serum triglycerides alone are less significant
– Must be studied as to their type • HDL is chiefly protein and soluble
– Increases with exercise and moderate alcohol consumption
– Decreases with smoking and diabetes • LDL contains 2/3 body’s
– Liver removes all it can metabolize
– Remainder processed peripherally
• Ingestion by macrophages in vessel begins damage • VLDL- chiefly triglycerides
– Made by liver to transport fats already in body.
– Burned for fuel or stored as fat Composition of The Body’s Serum Lipoproteins LDL is harmful because:
Excess must be processed
In tissues where damage occurs HDL is protective because:
-Inhibits cellular uptake of LDL
-Moves other lipids to liver for degredation
(“Reverse Cholesterol Transport”)...
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This document was uploaded on 02/07/2014.
- Spring '14