do lower heart attackstroke risk but cause other

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Unformatted text preview: bound) - may cause hemorrhage – Special caution: Any drug that binds to plasma proteins. Interactions often occur. Normal Clot Resolution Normal Thrombolytics Activate Plasminogen Plasminogen Plasmin Acts as Enzyme Breaks Fibrin and Fibrinogen Produces Products that Inhibit Coagulation Thrombolytic: Thrombolytic streptokinase, urokinase, anistreplase, recombinant tissue plasminogen activator (rTPA) streptokinase, urokinase, anistreplase, recombinant tissue plasminogen activator (rTPA) • Therapeutic Uses: – – – – – Acute pulmonary embolism Coronary thrombosis Some strokes Deep venous thrombosis Arterial clots • Contraindications: – Active bleeding tendencies – Cerebrovascular accident 2 hours old or more (approximately) – Tumor • Cautions: – Surgery or childbirth in the lasts few months – Watch for bleeding tendencies – Anaphylactic reactions possible Antilipemic Agents Antilipemic • Controversial drugs – most have severe side effects – overall unproven usefulness, general population... • do lower heart attack/stroke risk but… • cause other problems • Study June 1987 – – atherosclerosis can be reversed in less than 1/4 of the population • Cholesterol is associated with heart disease. • Serum triglycerides alone are less significant – Must be studied as to their type • HDL is chiefly protein and soluble phospholipids – Increases with exercise and moderate alcohol consumption – Decreases with smoking and diabetes • LDL contains 2/3 body’s cholesterol – Liver removes all it can metabolize – Remainder processed peripherally • Ingestion by macrophages in vessel begins damage • VLDL- chiefly triglycerides – Made by liver to transport fats already in body. – Burned for fuel or stored as fat Composition of The Body’s Serum Lipoproteins LDL is harmful because: Excess must be processed In tissues where damage occurs HDL is protective because: -Inhibits cellular uptake of LDL -Moves other lipids to liver for degredation (“Reverse Cholesterol Transport”)...
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This document was uploaded on 02/07/2014.

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