Unformatted text preview: Antilipemic Agents
Antilipemic • Fibroic Acid Derivatives - triglycerides
– Clofibrate (Atromid-S®)
– Gemfibrozil (Lopid®) • Niacin - Often used in combination
– Common skin flushing
• minimized by taking aspirin 30 min. prior to dose – Watch liver function tests
– Rare muscle pain if used in combination with statin. • Bile sequestrant - binds cholesterol
– Cholestyramine – note side effects
– NEW CATEGORY APPROVED (2003):
• Ezetimibe (Zetia®) prevents absorption cholesterol and
decreases LDL by 25% if used with Statins. • Statins (HMG-CoA reductase inhibitors).
Inhibits enzyme for cholesterol production. Antilipemic Agents
• Statins (HMG-CoA reductase inhibitors).
Inhibits enzyme for cholesterol production.
– Lovastatin (formerly mevinolin) approved late 1987
can lower cholesterol by 30 - 40%.
– Adverse effects uncommon but may be severe
• early cataract formation reported
• some liver function tests abnormal but no severe liver
disease noted yet
• myalgia, weakness, rhabdomyolysis. – Similar drugs show no advantages over lovastatin
so far, and some may be slightly less effective.
– Other agents include pravastatin, simvastatin, fluvastatin,
atorvastatin, and cerivastatin. Antilipemic Ag...
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- Spring '14
- toxic effects, Inhibitors Smooth Muscle, Autonomic modifiers