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Other agents include pravastatin simvastatin

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Unformatted text preview: Antilipemic Agents Antilipemic • Fibroic Acid Derivatives - triglycerides – Clofibrate (Atromid-S®) – Gemfibrozil (Lopid®) • Niacin - Often used in combination – Common skin flushing • minimized by taking aspirin 30 min. prior to dose – Watch liver function tests – Rare muscle pain if used in combination with statin. • Bile sequestrant - binds cholesterol – Cholestyramine – note side effects – NEW CATEGORY APPROVED (2003): • Ezetimibe (Zetia®) prevents absorption cholesterol and decreases LDL by 25% if used with Statins. • Statins (HMG-CoA reductase inhibitors). Inhibits enzyme for cholesterol production. Antilipemic Agents Antilipemic • Statins (HMG-CoA reductase inhibitors). Inhibits enzyme for cholesterol production. – Lovastatin (formerly mevinolin) approved late 1987 can lower cholesterol by 30 - 40%. – Adverse effects uncommon but may be severe • early cataract formation reported • some liver function tests abnormal but no severe liver disease noted yet • myalgia, weakness, rhabdomyolysis. – Similar drugs show no advantages over lovastatin so far, and some may be slightly less effective. – Other agents include pravastatin, simvastatin, fluvastatin, atorvastatin, and cerivastatin. Antilipemic Ag...
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