Hco3 loss may be balanced by tendency toward systemic

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Unformatted text preview: h are sulfonamide derivatives. • Caution: hypersensitivity possible in patients sensitive to sulfa drugs) • Na+ accompanies HCO3• Extra Na+ entering distal tubule may cause K+ depletion – Not as much acid-base upset as one might expect. HCO3- loss may be balanced by tendency toward systemic alkalosis at distal tubule. Ascending limb: Loop of Henle Ascending Inhibits Cl- reabsorption • Examples: – – – – – Thiazides to some extent Furosemide (Lasix®) Ethacrynic Acid (Edecrin®) Bumetanide (Bumex®) Torsemide (Demadex®) • Na+ accompanies Cl• Extra Na+ at distal tubule may cause K+ depletion – H+ secretion may now be a problem (especially with Lasix® and other Loop diuretics) Distal Convoluted Tubule Distal Potassium Sparing Diuretics • Frequently cause hyperkalemia • Spironolactone - aldosterone antagonist – only works well if aldosterone is high – causes Na+ diuresis and potassium retention • Direct action on tubule – mimics effects of aldosterone antagonist – effectiveness does not depend upon aldosterone levels but still causes Na+ diuresis and K+ retention. • (examples: triamterene and amiloride)...
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This document was uploaded on 02/07/2014.

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