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Unformatted text preview: h are sulfonamide derivatives.
• Caution: hypersensitivity possible in patients sensitive to
sulfa drugs) • Na+ accompanies HCO3• Extra Na+ entering distal tubule may cause K+
– Not as much acid-base upset as one might expect.
HCO3- loss may be balanced by tendency toward
systemic alkalosis at distal tubule. Ascending limb: Loop of Henle
Inhibits Cl- reabsorption
– Thiazides to some extent
Ethacrynic Acid (Edecrin®)
Torsemide (Demadex®) • Na+ accompanies Cl• Extra Na+ at distal tubule may cause K+ depletion
– H+ secretion may now be a problem (especially with
Lasix® and other Loop diuretics) Distal Convoluted Tubule
Potassium Sparing Diuretics
• Frequently cause hyperkalemia • Spironolactone - aldosterone antagonist
– only works well if aldosterone is high
– causes Na+ diuresis and potassium retention • Direct action on tubule
– mimics effects of aldosterone antagonist
– effectiveness does not depend upon
aldosterone levels but still causes Na+
diuresis and K+ retention.
• (examples: triamterene and amiloride)...
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This document was uploaded on 02/07/2014.
- Spring '14