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Generally function as antimetabolites or inhibitors

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Unformatted text preview: Antiseptic – agent used in living tissue that inhibits or kills microorganisms capable of producing infection – Not as strong as disinfectant. • Bactericide Some Terms: Some – An agent that kills bacteria independent of immune system. Generally affect bacterial cell walls or permeability of cell membrane. • Penicillins, cephalosporins, polymyxin, vancomycin. – Topicals must be bactericidal. • Bacteriostatic – A substance that inhibits growth and replication of bacteria. – Requires assistance from body’s immune system. Generally function as antimetabolites or inhibitors of protein synthesis. – Caution if infection - life-threatening or if host immune system malfunctioning. • s, sulfonamides, erythromycin, lincomycin. OBJECTIVE 5: OBJECTIVE • Identify factors that can contribute to the development of resistant bacterial strains. One Example of Resistance One Resistance: Resistance: the ability of a microorganism previously sensitive to an the antimicrobial agent to withstand the effects of that drug. antimicrobial • Resistance develops if: – Antiinfectives used in less than adequate doses. • Blood levels should be maintained by taking doses according to schedule whether oral or parenteral. – Treatment quit too soon. • Patient compliance often poor as they begin to feel better. – Antiinfective given unnecessarily Antiinfective given Antiinfective given unnecessarily unnecessarily • Treatment of untreatable infections – measles, mumps, chicken pox, and at least 90% of upper respiratory infections • Treating "fever". – Short duration - usually upper respiratory infection. – Long duration, one needs to identify cause • TB & abdominal abcess are common causes • Prophylaxis- when unwarranted or continued too long. Rubella Rubella Chicken Pox Chicken What can be done to help What avoid drug resistance? avoid • Develop better, more rapid identification methods – Identify the organism – Determine susceptibility or resistance to an antimicrobial before use • Educate patients – Take medicine on time – Finish the entire regimen – Good care sometimes includes NOT being given an antimicrobial...
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