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Unformatted text preview: Antiseptic
– agent used in living tissue that inhibits or kills
microorganisms capable of producing infection
– Not as strong as disinfectant. • Bactericide Some Terms:
Some – An agent that kills bacteria independent of immune system.
Generally affect bacterial cell walls or permeability of cell
• Penicillins, cephalosporins, polymyxin, vancomycin. – Topicals must be bactericidal. • Bacteriostatic
– A substance that inhibits growth and replication of bacteria.
– Requires assistance from body’s immune system. Generally
function as antimetabolites or inhibitors of protein synthesis.
– Caution if infection - life-threatening or if host immune system
• s, sulfonamides, erythromycin, lincomycin. OBJECTIVE 5:
• Identify factors that can contribute to the
development of resistant bacterial
strains. One Example of Resistance
the ability of a microorganism previously sensitive to an
antimicrobial agent to withstand the effects of that drug.
antimicrobial • Resistance develops if:
– Antiinfectives used in less than adequate
• Blood levels should be maintained by taking
doses according to schedule whether oral or
parenteral. – Treatment quit too soon.
• Patient compliance often poor as they begin to
feel better. – Antiinfective given unnecessarily Antiinfective given
• Treatment of untreatable infections
– measles, mumps, chicken pox, and at least 90%
of upper respiratory infections • Treating "fever".
– Short duration - usually upper respiratory infection.
– Long duration, one needs to identify cause
• TB & abdominal abcess are common causes • Prophylaxis- when unwarranted or continued
too long. Rubella
Rubella Chicken Pox
Chicken What can be done to help
avoid drug resistance?
• Develop better, more rapid identification
– Identify the organism
– Determine susceptibility or resistance to an
antimicrobial before use • Educate patients
– Take medicine on time
– Finish the entire regimen
– Good care sometimes includes NOT being given
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This document was uploaded on 02/07/2014.
- Spring '14