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Unformatted text preview: sidence relative to cells
Intracellular / Extracellular Antiinfective Therapy:
Determined by the organism
Empiric Therapy (Best Guess) - Determined by:
– Probable organisms (use clues:)
• site of infection (Organism?, Penetrance to site?)
• exposure to an organism
• Gram stain Focal Therapy (Narrower, more targeted)
– gram stain
– sensitivity tests (taken before any antibiotic given).
• Kirby-Bauer (disk diffusion) not very quantitative.
• Minimum Inhibitory Concentration (MIC) involve serial dilutions
of antibiotics in solid agar or broth media.
MIC prevents visible growth in 18 - 24 hours. The Drug
• Antimicrobial Spectrum
• Pharmacokinetics –
– bioavailability, distribution, elimination
– Will it reach the infection in high enough concentration
• (especially significant for brain, eye, joint, testes, abscess) • Ease of administration
– IV vs. PO
– often determines compliance • Relative safety
– side effects, toxicities, drug interactions
Many antimicrobials should not be taken with food, milk, or acidic
substances. The Patient
• Co-morbid conditions affecting safety or
effectiveness of drug
• Other medications being used
• Ability to comply with regimen Objective 8:
Objective Match antiinfectives with a brief description:
atch antiinfectives • Bactericidal
Aminoglycocides including Str...
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This document was uploaded on 02/07/2014.
- Spring '14