Antimetabolites inhibits dna synthesis s phase of

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Unformatted text preview: sistance • Need 100% kill because one cell can cause relapse (WBC’s help) Cancer Treatment Options: Cancer • Surgery - if localized (1/3 of all cancers) • Radiation – Perhaps dangerous to reach surgically – With some cancers this is first choice • Hormone therapy - only some tumors – Reproductive tumors, leukemias • Chemotherapy • Angiogenesis inhibitors Categories of Chemotherapeutic Agents: Categories • Alkylating agents (toxic to all cells, all stages) – Damages DNA at any stage during the growth cycle. – For slow growing cancers that don’t enter the cycle. Categories of Chemotherapeutic Agents: Categories • Alkylating agents (toxic to all cells, all stages) – Damages DNA at any stage during the growth cycle. – For slow growing cancers that don’t enter the cycle. • Plant Alkaloids (inhibits at metaphase) – less bone marrow depression – used for very ill patient. • Antimetabolites (inhibits DNA synthesis) – S phase of cycle – Resembles required substances(i.e. folic acid) Normal Cell Molecule Normal Antimetabolite (Chemotherapeutic Agent) Categories of Chemotherapeutic Agents: Categories • Alkylating agents (toxic to all cells, all stages) – Damages DNA at any stage during the growth cycle. ...
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This document was uploaded on 02/07/2014.

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