Cipro levoflox gatifloxacin dna thfa mrna folic acid

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Unformatted text preview: eptomycin Quinolones • Bacteriostatic Macrolides including Erythromycin Lincosamides Sulfonamides Trimethoprim Mechanisms of Action Cell wall synthesis (PBPs) DNA gyrase/Topoisomerase Penicillins, Cephalosporins Monobactams, Carbapenems Glycopeptides (Vancomycin) Quinolones - Cipro Levoflox Gatifloxacin DNA THFA mRNA Folic acid metabolism DHFA Trimethoprim Sulfonamides Ribosomes 50 30 50 30 Protein synthesis (50S inhibitors) 50 30 Macrolides Clindamycin PABA Cell Membrane polymyxins Protein synthesis (30S inhibitors) Aminoglycosides Protein synthesis (tRNA) Mupirocin Gram Positive Gram Gram Negative More Complex Cell Wall Simpler Cell Wall pili Surface Proteins Outer Membrane Outer Peptidoglycan Contains Endotoxin Endotoxin Penetrated by Porins Penetrated Porins Mechanisms of Action Antimicrobials include: • Beta-Lactams • Glycopeptides Cell wall synthesis (PBPs) DNA THFA mRNA DHFA Ribosomes 50 30 PABA 50 30 50 30 4 Beta-Lactam Antibiotic Families Beta-Lactam Antibiotic Most penicillins are produced by attaching Most...
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This document was uploaded on 02/07/2014.

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