Effects caution renal failure reduce dose monobactams

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Unformatted text preview: s ((Imipenem, Meropenem) Carbipenems Imipenem, Meropenem Meropenem) • Also has a beta lactam ring – Resistant to penicillinase – Used with cilastin which inhibits renal secretion • Similar to penicillins in: – Mechanism: • Inhibits crosslinking of cell wall components – Spectrum (wider): • Most gram positive and negatives including penicillinase resistant • Includes Pseudomonas aeruginosa – Side Effects: • Caution renal failure, reduce dose Monobactams ((aztreonam Azactam®) Monobactams aztreonam Azactam®) • Mechanism of action similar to penicillins. • Unique antibacterial spectrum. – Less effective against gram positive organisms – Very effective against troublesome gram negative organisms. • Other Features: – Similar in usefulness to aminoglycosides. – Little or no cross-allergenicity to penicillins and cephalosporins. Glycopeptides Glycopeptides (vancomycin, bacitracin) vancomycin, bacitracin bacitracin) • Inhibit cell wall synthesis but do not have a beta-lactam structure. • Bactericidal • Major toxicity limits systemic use except in resistant hospital based infections. – Vancomycin may be drug of choice for some types of colitis because it does not absorb well and remains in the intestine....
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