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Folic acid use low cost ease of administration kidney

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Unformatted text preview: • Typhoid fever • Some meningeal infections (especially if caused by H. influenzae resistant to ampicillin), • Some systemic Salmonella infections • Some anaerobic infections (especially Bacteroides fragilis) • Problems: – Infant unable to eliminate. – Blood abnormalities (may appear after therapy has ceased) – Blood checks are recommended twice weekly. Use other less toxic therapy first. Mechanisms of Action DNA THFA mRNA Folic acid metabolism DHFA Trimethoprim Sulfonamides Ribosomes 50 30 PABA 50 30 50 30 Sulfonamides Sulfonamides • • • • • Broad spectrum; bacteriostatic (inh. Folic acid use) Low cost, ease of administration Kidney damage possible (use with lots of water) Resistance common--maintain therapy Especially used for: – Otitis media and urinary and vaginal infections. • Sulfisoxazole (Gantrisin®) is an example of a more water soluble form that is rapidly absorbed and eliminated. Good for urinary tract infections which are usually caused by E. coli or Proteus mirabilis. Pediaz...
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