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Unformatted text preview: • Typhoid fever
• Some meningeal infections (especially if caused by H. influenzae
resistant to ampicillin),
• Some systemic Salmonella infections
• Some anaerobic infections (especially Bacteroides fragilis) • Problems:
– Infant unable to eliminate.
– Blood abnormalities (may appear after therapy has ceased)
– Blood checks are recommended twice weekly. Use other less toxic therapy first. Mechanisms of Action DNA
mRNA Folic acid
metabolism DHFA Trimethoprim
30 PABA 50
• Broad spectrum; bacteriostatic (inh. Folic acid use)
Low cost, ease of administration
Kidney damage possible (use with lots of water)
Resistance common--maintain therapy
Especially used for:
– Otitis media and urinary and vaginal infections.
• Sulfisoxazole (Gantrisin®) is an example of a more water soluble form
that is rapidly absorbed and eliminated. Good for urinary tract infections
which are usually caused by E. coli or Proteus mirabilis. Pediaz...
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- Spring '14