However if gram negative bacteria on hands then 1

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Unformatted text preview: ectrum highly desirable rapid onset and sustained activity desirable lipid solubility for penetration of epidermis • Presence of foreign matter - blood, pus, cell debris • Nature of organism – Capsule or spore – Are open wounds infective • Social attitude – Acceptance of treatment – Preventing reinfection or family infection Topicals: On Skin Topicals: • Longevity – Chlorhexidine or hexachlorophene last much longer • 26% of chlorhexidine remains active on skin 29 hrs – Povidone-iodine (Betadine®) lasts as long as Iodine • persists several hours • Bacterial Activity – 1% iodine tincture and chlorhexidine reduce bacterial population much more effectively than 10 % povidone-iodine. – However, if gram-negative bacteria on hands then: • 1% tincture of iodine best • then povidone-iodine • then chlorhexidine – 84% of hospital strains of Pseudomonas aeruginosa have some resistance Topicals: On Instruments Topicals: • Heat sterilization where possible • Gas sterilization - Ethylene oxide • Very effective - broad spectru...
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