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Unformatted text preview: ole® =
sulfisoxazole and erythromycin.
• Trimethoprim-sulfamethoxazole (TMP-SMZ) is an especially effective
combination with a greatly expanded spectrum. Uses: urinary tract
infections, bacterial respiratory infections, gastrointestinal infections.
– Septra® , Bactrim ® , and others. Note That We Have Skipped:
– Amantadine (virus does not enter susceptible cells)
– (inhibits DNA polymerase at thymine) • Antifungals (disrupt fungal cell membranes)
– amphotericin B
– Nystatin • Antiparasitic agents
– Metronidazole (Flagyl®)
• Bind DNA in anerobes but mechanism in parasites is unknown See articles. Objective 9
• Identify factors which must be considered
when selecting an antiinfective agent for
topical use. Considerations: Topical Antiinfectives
• Effectiveness vs. tissue destruction
• Nature and concentration of antiseptic
– some are disinfectants as well
germicidal not germistatic
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This document was uploaded on 02/07/2014.
- Spring '14