Other protein synthesis inhibitors are bacteriostatic

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Unformatted text preview: – Bacitracin is chiefly a topical agent because of its toxicity. Inhibitors of Cell Wall Biosynthesis R • Beta-Lactams – – – – – R N O R Penicillins Cephalosporins R Carbapenems Monobactams Beta-Lactamase inhibitor combinations • Glycopeptides – Vancomycin – Bacitracin O R N R Mechanisms of Action DNA THFA mRNA DHFA Ribosomes 50 30 50 30 50 30 PABA Protein synthesis (30S inhibitors) Aminoglycosides Aminoglycosides are bactericidal. Other protein synthesis inhibitors are bacteriostatic. Aminoglycosides Aminoglycosides (streptomycin, amikacin, gentamicin, kanamycin, neomycin, netilmicin, (streptomycin, amikacin gentamicin kanamycin neomycin, netilmicin amikacin, gentamicin, kanamycin, netilmicin, paromomycin, tobramycin.) paromomycin tobramycin.) aromomycin, tobramycin.) • Broad spectrum , bacteriocidal – Especially useful on aerobic gram negative organisms (i.e. Enterobacter, E. coli, Klebsiella pneumoniae, Proteus, Serratia, Pseudomonas, for TB). Not...
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