Precipitates in acid urine avoid prune plum cranberry

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Unformatted text preview: for anaerobic bacteria. – Often used with penicillins or cephalosporins • Has poor permiability – helps it enter the cell to work – Used with sensitivity tests (resistance develops). If possible use less toxic antibiotics first. • Other issues: – Hearing loss (renal function?), neuromuscular blocking ( low Ca++?) – Use parenterally unless for GI parasites as when treating hepatic coma or prior to bowel surgery (not absorbed). – Does not cross blood brain barrier adequately. – Precipitates in acid urine. Avoid prune, plum, cranberry juice. Mechanisms of Action DNA gyrase/Topoisomerase Quinolones - Cipro Levoflox Gatifloxacin DNA THFA mRNA DHFA Ribosomes 50 30 PABA 50 30 50 30 Quinolones and Fluoroquinolones Quinolones and Fluoroquinolones • Broad spectrum, prevents bacterial DNA replication – Strong and rapid bactericidal action against most gram-negative and many gram-positive organisms. – First orally active agents against Pseudomonas. • Other issues: – Twice daily dosing is standard (longer half-life). – Little cross resistance with other antibiotics. – Fewer adverse reactions • Can cause nausea, rashes, visual disturbances, depressed bone marrow. – Cartilage erosion in young dogs and rats explains contraindications in pregnant...
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