Unformatted text preview: for anaerobic bacteria.
– Often used with penicillins or cephalosporins
• Has poor permiability – helps it enter the cell to work – Used with sensitivity tests (resistance develops). If possible use
less toxic antibiotics first. • Other issues:
– Hearing loss (renal function?), neuromuscular blocking ( low Ca++?)
– Use parenterally unless for GI parasites as when treating hepatic
coma or prior to bowel surgery (not absorbed).
– Does not cross blood brain barrier adequately.
– Precipitates in acid urine. Avoid prune, plum, cranberry juice. Mechanisms of Action
Quinolones - Cipro
30 PABA 50
30 Quinolones and Fluoroquinolones
Quinolones and Fluoroquinolones
• Broad spectrum, prevents bacterial DNA replication
– Strong and rapid bactericidal action against most gram-negative
and many gram-positive organisms.
– First orally active agents against Pseudomonas. • Other issues:
– Twice daily dosing is standard (longer half-life).
– Little cross resistance with other antibiotics.
– Fewer adverse reactions
• Can cause nausea, rashes, visual disturbances, depressed bone marrow. – Cartilage erosion in young dogs and rats explains contraindications
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- Spring '14