Spectrum similar to penicillin chiefly gram positive

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Unformatted text preview: or nursing women or in children under 18 years old. • Examples: – Ciprofloxacin (Cipro®) - serious infections with resistant strains. – Norfloxacin and ofloxacin - for urinary tract infections only. Mechanisms of Action DNA THFA mRNA DHFA Ribosomes 50 30 50 30 50 30 Protein synthesis (50S inhibitors) Macrolides Lincosamides PABA Protein synthesis (30S inhibitors) Aminoglycosides Macrolides: Macrolides: Erythromycin Erythromycin • Often used in patients allergic to penicillin. – Spectrum similar to penicillin - chiefly gram positive; some gram negative organisms. – Concentrates in macrophages, has some antiinflammatory effects • Useful in Respiratory infection including cystic fibrosis – Resistant strains develop easily – Allergic reactions may occur. – Otherwise low toxicity though GI may be problem • Bacteriostatic inhibits protein synthesis. Other examples: Clarithromycin, Azithromycin, Roxithromycin Recently found that some newer macrolides concentrate in macrophages...
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