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Unformatted text preview: or nursing women or in children under 18 years old. • Examples:
– Ciprofloxacin (Cipro®) - serious infections with resistant strains.
– Norfloxacin and ofloxacin - for urinary tract infections only. Mechanisms of Action DNA
30 Protein synthesis
Macrolides Lincosamides PABA Protein synthesis
(30S inhibitors) Aminoglycosides Macrolides:
Erythromycin • Often used in patients allergic to penicillin.
– Spectrum similar to penicillin - chiefly gram positive; some
gram negative organisms.
– Concentrates in macrophages, has some antiinflammatory
• Useful in Respiratory infection including cystic fibrosis – Resistant strains develop easily
– Allergic reactions may occur.
– Otherwise low toxicity though GI may be problem • Bacteriostatic inhibits protein synthesis.
Other examples: Clarithromycin, Azithromycin,
Recently found that some newer macrolides concentrate in macrophages...
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- Spring '14