Sulbactam another beta lactamase inhibitor that is

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Unformatted text preview: ctamase Inhibitors Beta-Lactamase Ways to “Rejuvenate”Penicillins Ways “Rejuvenate”Penicillins • Clavulanic acid – Beta lactamase inhibitor is being used against penicillinase producing Staph., H. influenzae, & E. coli. – Currently marketed in combination with amoxicillin (Augmentin®) and ticarcillin (Timentin®). • Sulbactam – Another beta lactamase inhibitor that is being used with ampicillin (Unasyn®). • Tazobactam – Another “rejuvenator” used with piperacillin (Zosyn) • Probenecid – – An antigout medication that inhibits renal tubular secretion of many agents including penicillins and cephalosporins. – Increase the half-life of these drugs in the body and, therefore, reduce the frequency of administration. 4 Beta-Lactam Antibiotic Families Beta-Lactam Antibiotic Cephalosporins Cephalosporins • Similar to penicillins in: – Structure, mechanism, and spectrum – Somewhat less active against most gram positive organisms so penicillin still first choice in most cases. – May be first choice for: • Serious Klebsiella infections (either with or without aminoglycosides) • Prophylaxis before, during, and after surgery • Meningitis caused by gram negative enteric bacteria. • Advantage - resistant to penicillinase • Disadvantages – probably allergic cross-sensitivity exists with penicillins – must use with sensitivity tests - only effective sometimes 4 Beta-Lactam Antibiotic Families Beta-Lactam Antibiotic Carbipenem...
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This document was uploaded on 02/07/2014.

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