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Unformatted text preview: oxicity - Often Dose and Time Related
– Skin, GI, Kidney, Liver, Blood, Neurological reactions,
Ototoxicity OBJECTIVE 7:
• Discuss important factors in selecting
an antiinfective agent. Systemic Vs. Topical Therapy
• Treatment of existing infection
– Generally, systemic therapy more effective
• Exceptions: Burns, superficial fungal infections, or in patients
who have resistance or intolerance to systemic
antimicrobials. • Prophylactic Antisepsis before surgery
• Environmental pathogens (instruments, hands, etc.)
• Patient's skin (Important, but less so than instruments) – Systemic - recommended only for some surgeries.
• "Clean" surgeries have only a 5% risk of infection (cefazolin).
If bowel involved, cefoxitin may be a better choice. Antimicrobial Selection:
• The Organism
• The Drug
• The Patient Classification of Common Pathogens
Classification of Common Pathogens
• Gram Stain (hematoxylin stain)
Gram Positive / Gram Negative • Shape
Cocci / Bacilli • Tolerance or need for oxygen
Aerobic / Anaerobic / Facultatively Anaerobic • Site of re...
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This document was uploaded on 02/07/2014.
- Spring '14