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Unformatted text preview: mpairment of normal cellular maturation
– Undifferentiated cells (often no useful function) Antineoplastic Agents
Drugs to Treat Cancer • What is cancer?
– A disease of cells characterized by:
• Impairment of normal cellular control
– Invasive and able to metastasize
– Does not respond to cell contact • Impairment of normal cellular maturation
– Undifferentiated cells (often no useful function) • Impairment of normal cellular division.
– Excessive cell growth (due to lack of regulation) Antineoplastic Agents
Drugs to Treat Cancer • Why does this lead to illness or death?
– Pressure from tumor growth
– Destruction of organ
– Systemic Competition for:
• Waste disposal G0
Variable Length Why is the Cell Cycle Important
to Cancer Chemotherapy?
• “Stable" cancer is in G0
– difficult to kill with cycle specific drugs • Cells are in different stages
– combinations of drugs are more effective
than single agents • More kill = less re...
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This document was uploaded on 02/07/2014.
- Spring '14