Example cimetidine tagamet anticholinergic drugs

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Unformatted text preview: Side Effects - not serious – Al or Ca causes constipation – Mg causes diarrhea • Combination of two types often helps avoid problem. (Example: Maalox®, Gelusil®, Digel®, and others). • Also, Al compounds have a slower onset while Mg acts more quickly. Combination good. • Caution: Antacids alter absorption of many drugs. Particularly important if kidney or liver disease. Sedative or Antisecretory Agents Sedative Antisecretory Agents inhibit secretion by different mechanisms • H2 antagonists - inhibit gastric secretion. – Example: Cimetidine (Tagamet®) • Anticholinergic drugs (example: Donnatal®) • Prostaglandins - misoprostol (Cytotec®) – Reduces acid, increases mucus secretion. – Contraindicated in pregnancy (miscarriage has occurred). • Proton Pump Inhibitors • esomeprazole (Nexium®), lansoprazole (Prevacid®), omerprazole (Losec®, Prilosec®), pantoprazole (Protonix®), rabeprazole (Aciphex®) – Short-term use (4-8 weeks). – Directly diffuses into gastric epithelium to suppress acid secretion. Agents That Increase Gastric Emptying Agents Seems to increase sensitivity t...
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