Unformatted text preview: Side Effects - not serious
– Al or Ca causes constipation
– Mg causes diarrhea
• Combination of two types often helps avoid problem. (Example:
Maalox®, Gelusil®, Digel®, and others).
• Also, Al compounds have a slower onset while Mg acts more quickly.
Combination good. • Caution: Antacids alter absorption of many drugs.
Particularly important if kidney or liver disease. Sedative or Antisecretory Agents
Sedative Antisecretory Agents
inhibit secretion by different mechanisms
• H2 antagonists - inhibit gastric secretion.
– Example: Cimetidine (Tagamet®) • Anticholinergic drugs (example: Donnatal®)
• Prostaglandins - misoprostol (Cytotec®)
– Reduces acid, increases mucus secretion.
– Contraindicated in pregnancy (miscarriage has occurred). • Proton Pump Inhibitors
• esomeprazole (Nexium®), lansoprazole (Prevacid®), omerprazole
(Losec®, Prilosec®), pantoprazole (Protonix®), rabeprazole
(Aciphex®) – Short-term use (4-8 weeks).
– Directly diffuses into gastric epithelium to suppress acid
secretion. Agents That Increase Gastric Emptying
Seems to increase sensitivity t...
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- Spring '14
- Histamine, therapeutic uses