More sedating but also more useful as a sedative for

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Unformatted text preview: Histamine Antagonist is a better term – compete with histamine for H1 or H2 receptor sites – Most antihistaminics are H1 antagonists H1 Antagonists “Antihistamines” “Antihistamines” H1 • First Generation types bind both centrally (CNS effects) and peripherally. – More sedating but also more useful as a sedative, for motion sickness, or in special cases for treating Parkinson’s (see Unit 6). – Examples: chlorpheniramine (Chlortrimeton®), clemastine (Tavist-D®), promethazine (Phenergan®) • Second Generation types – Less drowsiness. – These newer agents can produce adverse cardiovascular effects (hypo- or hypertension, syncope, tachycardia). – Examples: azelastine (Astelin®), cetirizine (Zyrtec®), fexofenadine (Allegra®), and loratadine (Claritin®) Therapeutic Uses –H1Antagonists Therapeutic –H1Antagonists • Antagonize allergic reactions (hives, watery eyes, stuffy nose--but NOT asthma!) – prevent more symptoms from occurring – less effective than epinephrine at counteracting react...
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This document was uploaded on 02/07/2014.

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