Nasal decongestants nasal adrenergic agents mechanism

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Unformatted text preview: ace active drugs (Ethanols) Diluents (water or saline) Dornase Alfa, a DNAase (Pulmozyme®) specifically for cystic fibrosis. – Viscosity increases due to DNA which comes from lysed inflammatory cells. Nasal Decongestants Nasal • Adrenergic agents – Mechanism of Action - nasal vasoconstriction – Caution: habituation occurs • Antihistaminics – OK for allergy, may help relieve cold symptoms • Intranasal Steroids - allergy. – May increase risk of thrush and prevent healing of damaged nasal mucosa Objective 4 Objective • Describe the effects of histamine and identify therapeutic uses, common side effects, and cautions for the histamine antagonizing drugs. What Histamine Does What • Contraction of bronchial and intestinal smooth muscle – H1 receptors • Dilation of arterioles and capillaries and increases permeability – H1 receptors • Increases gastric acid secretion – H2 receptors Histamine Antagonizing Drugs Histamine • Produce opposite effects as histamine (epinephrine) – good for counteracting symptoms of reaction that has occurred. Only minor effect on histamine release. • Prevent histamine reaction –”antihistamines”...
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