Unformatted text preview: o acetylcholine
– cisapride (Propulsid®), metoclopramide
(Reglan®) • Relaxes pylorus and stimulates motility.
• Relieves heartburn and nausea caused by
gaseous distention. About Ulcers:
• Older ulcer treatments focused on antacids.
– Best to use antacids ® times per day at 1 and 3 hours
after each meal and at bedtime.
– Not quite as effective as H2 antagonists, but not as much
rebound ulceration. • Note: Sucralfate (Carafate®), aluminum hydroxide
and sulfate sucrose
– minimal antacid effect
– adheres to ulcerated region (protecting it) and decreasing
– Sucralfate is as effective as H2 antagonists at healing. It's
best used before meals and before antacids because it
needs some acid to become active. Submucosa: Nerve & Lymph Network
Benign vs. Cancer Modern ulcer therapy:
• The bacterium Heliobacter pylori is present in the
majority of ulcer cases so therapy should include:
– an antisecretory agent, especially an H2 antagonist or proton
– Bismuth (Pepto-Bismol®) to reduce bacterial adherence to
mucosal cells and damage bacterial cell walls
– At least 2 antibiotics to avoid resistance.
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This document was uploaded on 02/07/2014.
- Spring '14