Therapeutic uses h2 antagonists therapeutic decrease

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Unformatted text preview: n eye solutions for eye allergies. – Neither agent is an antihistaminic that competes for H1 receptor sites. • Do periodic blood tests (check for blood dyscrasias) H2 antagonists H2 • Block a second type of histamine receptors: – – – – cimetidine (Tagamet®) famotidine (Pepcid®) nizatidine (Axid®) rantidine (Zantac®) • These agents are not antihistamines as we know them. Therapeutic Uses: H2 antagonists Therapeutic • Decrease gastric secretion (ulcer patients) • Treat heartburn (esophageal reflux) -unapproved use – Preliminary studies look promising for this use. Side Effects: H2 Antagonists Side • Minimal – Does not cause usual sedation in most patients. – Occasionally, causes diarrhea, muscle pain, rash, dizziness. – Also, because inhibits P450 enzymes, can delay metabolism of other drugs in liver. • Very rare – breast enlargement in some men – mental confusion in older patients. GI Drugs GI • Affect: – muscular and/or glandular tissue of G.I. tract – either directly or indirectly via ANS. • Basically, discussion will: – start with stomach – and work toward intestines. Objective 5 Objective • For the following GI drugs identify: – Therapeutic uses – Common side or toxic effects – Contraindications and Cautions, if any • • • • • • • Antacids and other acid inhibitors Digestants Emetics Antiemetics Cathartics Antidiarrheics Carminatives Antacids and other acid inhibitors Antacids • Therapeutic Uses...
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