Lecture_4_motifs

# 033646 probaaacct p scoring strings with a prole

This preview shows page 1. Sign up to view the full content.

This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: as the probability that an L- mer a was created by the Proﬁle P Scoring Strings with a Proﬁle Scoring Strings with a Proﬁle Given a proﬁle P = A 1/2 7/8 3/8 1/2 C 1/8 0 T 1/8 1/8 0 G 1/4 0 1/8 0 1/8 0 5/8 3/8 0 0 1/4 7/8 3/8 1/4 1/8 The probability of the consensus string: P rob(a|P ) = QL i=1 pai ,i •  If a is very similar to the consensus string of P then Prob(a | P) will be high •  Otherwise, if a is very diﬀerent then Prob(a | P) will be low Given a proﬁle P = A 1/2 7/8 3/8 1/2 C 1/8 0 T 1/8 1/8 0 G 1/4 0 1/8 0 1/8 5/8 3/8 0 0 0 1/4 7/8 3/8 1/4 1/8 The probability of the consensus string: Prob(aaacct | P) = 1/2 x 7/8 x 3/8 x 5/8 x 3/8 x 7/8 = .033646 Prob(aaacct | P) ? Scoring Strings with a Proﬁle Given a proﬁle P = A 1/2 7/8 3/8 1/2 C 1/8 0 T 1/8 1/8 0 G 1/4 0 1/8 0 1/8 0 5/8 3/8 0 0 1/4 1/4 Deﬁne the P- most probable L- mer from a sequence as an L-mer in that sequence which has...
View Full Document

## This note was uploaded on 02/10/2014 for the course CS 425 taught by Professor Asaben-hur during the Fall '13 term at Colorado State.

Ask a homework question - tutors are online