Lecture_4_motifs

033646 probaaacct p scoring strings with a prole

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Unformatted text preview: as the probability that an L- mer a was created by the Profile P Scoring Strings with a Profile Scoring Strings with a Profile Given a profile P = A 1/2 7/8 3/8 1/2 C 1/8 0 T 1/8 1/8 0 G 1/4 0 1/8 0 1/8 0 5/8 3/8 0 0 1/4 7/8 3/8 1/4 1/8 The probability of the consensus string: P rob(a|P ) = QL i=1 pai ,i •  If a is very similar to the consensus string of P then Prob(a | P) will be high •  Otherwise, if a is very different then Prob(a | P) will be low Given a profile P = A 1/2 7/8 3/8 1/2 C 1/8 0 T 1/8 1/8 0 G 1/4 0 1/8 0 1/8 5/8 3/8 0 0 0 1/4 7/8 3/8 1/4 1/8 The probability of the consensus string: Prob(aaacct | P) = 1/2 x 7/8 x 3/8 x 5/8 x 3/8 x 7/8 = .033646 Prob(aaacct | P) ? Scoring Strings with a Profile Given a profile P = A 1/2 7/8 3/8 1/2 C 1/8 0 T 1/8 1/8 0 G 1/4 0 1/8 0 1/8 0 5/8 3/8 0 0 1/4 1/4 Define the P- most probable L- mer from a sequence as an L-mer in that sequence which has...
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This note was uploaded on 02/10/2014 for the course CS 425 taught by Professor Asaben-hur during the Fall '13 term at Colorado State.

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