This preview shows page 1. Sign up to view the full content.
Unformatted text preview: as the probability that an L mer a was created by the Proﬁle P Scoring Strings with a Proﬁle Scoring Strings with a Proﬁle Given a proﬁle P = A 1/2 7/8 3/8
1/2 C 1/8 0
T
1/8
1/8
0 G 1/4 0
1/8 0 1/8 0 5/8 3/8 0 0 1/4 7/8 3/8 1/4 1/8 The probability of the consensus string: P rob(aP ) = QL i=1 pai ,i • If a is very similar to the consensus string of P then Prob(a  P) will be high • Otherwise, if a is very diﬀerent then Prob(a  P) will be low Given a proﬁle P = A 1/2 7/8 3/8
1/2 C 1/8 0
T
1/8
1/8
0 G 1/4 0
1/8 0 1/8 5/8 3/8 0
0 0 1/4 7/8 3/8 1/4 1/8 The probability of the consensus string: Prob(aaacct  P) = 1/2 x 7/8 x 3/8 x 5/8 x 3/8 x 7/8 = .033646 Prob(aaacct  P) ? Scoring Strings with a Proﬁle Given a proﬁle P = A 1/2 7/8 3/8
1/2 C 1/8 0
T
1/8
1/8
0 G 1/4 0
1/8 0 1/8 0 5/8 3/8 0 0 1/4
1/4 Deﬁne the P most probable L mer from a sequence as an Lmer in that sequence which has...
View
Full
Document
This note was uploaded on 02/10/2014 for the course CS 425 taught by Professor Asabenhur during the Fall '13 term at Colorado State.
 Fall '13
 AsaBenHur

Click to edit the document details