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Lecture_4_motifs

# 1 a a a c g t 2 a t a g c g 3 a a c c c t 4 g a a c c

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Unformatted text preview: ob(a | P) of any other 6- mer in the sequence. 0 ctataaaccttacat ctataaaccttacatc .0004 P- Most Probable L- mers in Many Sequences •  Find the P- most probable L- mer in each of the sequences. A P = 1/2 C T G 0 P- Most Probable L- mers in Many Sequences ctataaacgttacatc ctataaacgttacatc atagcgattcgactg 1 a a a c g t 2 a t a g c g cagcccagaaccct 3 a a c c c t 4 g a a c c t 5 a t a g c t g a c c t g cggtataccttacatc 7/8 3/8 0 1/8 1/8 0 1/2 5/8 3/8 0 tgcattcaatagctta 6 7 a t c c t 1/8 0 0 1/4 7/8 tatcctttccactcac 8 t a c c t t 1/4 0 1/8 3/8 1/4 1/8 A 5/8 5/8 4/8 0 0 0 cagcccagaaccct cggtgaaccttacatc t 1/8 atagcgattcgactg ctccaaatcctttaca ggtcatcctttatcct C 0 0 4/8 6/8 4/8 0 T 1/8 3/8 0 0 3/8 6/8 G 2/8 0 0 2/8 1/8 2/8 tgcattcaatagctta tgtcctgtccactcac ctccaaatcctttaca ggtctacctttatcct P- most probable L- mers form a new proﬁle 4 9/4/13 Greedy Proﬁle Mo0f Search Comparing New and Old Proﬁles Use P- most probable L- me...
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