Why should the proximal snps be correlated and distal

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Unformatted text preview: Control We are guided by two simple facts governing these muta/ons: 1.  Nearby muta/ons are correlated; 2.  Distal muta/ons are not. The Basics of Associa/on Mapping 0 0 0 0 1 1 1 1 Case Control •  Sample a popula/on of individuals at variant loca/ons across the genome. Typically, these variants are SNPs. •  Create a new bi ­allelic variant corresponding to cases and controls, and test for correla/ons. •  By our assump/ons, only the proximal variants will be correlated. •  Inves/gate genes near the correlated variants. Why should the proximal SNPs be correlated, and distal SNPs not? A Bit of Evolu/on Time •  Consider a fixed popula/on (of chromosomes)...
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This note was uploaded on 02/10/2014 for the course CS 680 taught by Professor Staff during the Fall '08 term at Colorado State.

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