{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Why should the proximal snps be correlated and distal

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Control We are guided by two simple facts governing these muta/ons: 1.  Nearby muta/ons are correlated; 2.  Distal muta/ons are not. The Basics of Associa/on Mapping 0 0 0 0 1 1 1 1 Case Control •  Sample a popula/on of individuals at variant loca/ons across the genome. Typically, these variants are SNPs. •  Create a new bi ­allelic variant corresponding to cases and controls, and test for correla/ons. •  By our assump/ons, only the proximal variants will be correlated. •  Inves/gate genes near the correlated variants. Why should the proximal SNPs be correlated, and distal SNPs not? A Bit of Evolu/on Time •  Consider a fixed popula/on (of chromosomes)...
View Full Document

{[ snackBarMessage ]}

Ask a homework question - tutors are online