A piece of dna is inserted into the genome at a

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Unformatted text preview: @on, eczema, and pigment defects that make affected individuals lighter skinned Polygenic inheritance in humans: Countless traits •  Height is controlled by polygenes for skeleton height, but their effect may be affected by [email protected], injury, and disease. •  Weight, skin color, and intelligence. •  Birth defects like clubfoot, clef palate, or neural tube defects are also the result of [email protected] gene [email protected] •  Complex diseases and traits have a tendency to have low heritability (tendency to be inherited) compared to single gene disorders (i.e. sickle ­cell anemia, [email protected] fibrosis, PKU, Hemophelia, many extremely rare [email protected] disorders). [email protected] •  Some genes may be subject to selec4on, where individuals with advantages or [email protected] traits tend to be more successful than their peers [email protected] •  When these traits have a [email protected] basis, [email protected] can increase the prevalence of those traits, because the offspring will inherit those traits. This may correlate with the organism's ability to survive in its environment. •  Several different genotypes (and possibly phenotypes) may then coexist in a [email protected] In this case, their [email protected] differences are called polymorphisms. [email protected] [email protected] •  The simplest is the point [email protected] or [email protected]@on; here, a single [email protected] in the genome is changed (single nucleo4de polymorphisms (SNPs)) •  Other types of [email protected] include the following: –  Inser4on. A piece of DNA is inserted into the genome at a certain [email protected] –  Dele4on. A piece of DNA is cut from the genome at a certain [email protected] –  Inversion. A piece of DNA is cut, flipped around and then re ­ inserted, thereby [email protected] it into its complement –  Transloca4on. A piece of DNA is moved to a differen...
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This note was uploaded on 02/10/2014 for the course CS 680 taught by Professor Staff during the Fall '08 term at Colorado State.

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