Chapter 4 lecture notes

Enanaomers sold as a mixture or both enantomers s 100x

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ngements about a double bond EnanKomers Isomers that are mirror images of each other * enantiomers have an asymmetric carbon Asymmetric carbon: When the C is bound to 4 different atoms or groups of atoms The pharmacological importance of enanAomers Sold as a mixture or both enanTomers * S 100x more effective Only R is sold. * S counteracts effects of R Thalidomide: Drug used in the 1950’s to treat morning sickness. Composed of two enaTomers R(+) enanTomer has a sedaTve effect S( ­): highly teratogenic (birth defects) R(+) is converted to S( ­) in the body h"p://nimbime.files.wordpress.com/ 2007/06/thalidomide.png Serious Consequences: exposure of this drug inhibited the formation of new blood vessels in the limbs of a developing embryo Phocomelia 28 days 35 days Thalidomide Exposure (Between Day 39 – 41 of gestaTon) 42 days h"p://www.chm.bris.ac.uk/motm/thalidomide/...
View Full Document

This document was uploaded on 02/10/2014.

Ask a homework question - tutors are online