2 20100 02 100 frequencies in populaon

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: s = q p + q = 1 Expected genotype frequencies: AA Aa aa P2 2pq q2 Assump'ons of the Hardy- Weinberg equilibrium - Very large popula%on size. - Random ma%ng. - No selec%on. - No migra%on. - No muta%on. ***If these condi%ons are met, allele and genotype frequencies will remain constant from genera%on to genera%on.*** Life cycle… “Punne4 square” A (p) a (q) AA (__) A (p) Aa (__) a (q) Aa (__) aa (__) How H- W equilibrium can be violated (detec%on of evolu%onary change) “Punne4 square” A (p) a (q) AA (p2) A (p) Aa (__) a (q) Aa (__) aa (q2) “Punne4 square” A (p) a (q) AA (p2) A (p) Aa (pq) a (q) Aa (pq) aa (q2) That is equivalent to the binomial expansion: (p + q )2 = p2 + 2pq + q2 For three alleles at a locus: (p + q + r)2 = p2 + q2 + r2 + 2pq + 2pr + 2qr Calcula%ng allele frequencies (p and q) using genotypic frequencies: AA Aa aa p2 2pq q2 Frequency of A = p2 + (2pq)/2 = p2 + pq Replacing q by (1-...
View Full Document

Ask a homework question - tutors are online