Lect_6_MutationVariation

Method 1 coun6ng alleles in this case there are two

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Unformatted text preview: 6on of heterozygotes at this locus is: 9/17 = 0.53 9 In many species 2/3 - 3/4 of all loci are polymorphic and the average individual is heterozygous at 25% to 33% of all its loci. That means that: In Drosophila, with 13,000 genes, there would be about 3,000 heterozygous genes per individual. In humans, with approx. 20,000- 30,000 genes, there would be about 5,000- 7,500 heterozygous genes per individual. However, ……. electrophoresis underes6mates gene6c variability. Methods that examine DNA directly are more sensi6ve for detec6ng gene6c variability. DNA sequence varia6on In humans: 1 difference each 1,000 bases With genome size of 3.2 billion nucleo6des (3,200 Mb), one human differs from another at about 3.2 million nucleo6de sites on average. Charles Darwin (1809- 1882) Gregor Mendel (1822- 1884) •  Origin of new gene6c varia6on (OLD NEWS) •  How were heritable traits passed on from parent to offspring? –  Mendel discovered basic laws of heredity and solved problem of why offspring look like their parents (FOCUS FOR REST OF TODAY) Popula.on Gene.cs VARIATION MODELS Selec6on, drin, muta6on, migra6on Pa]ern (data) Infer process and mechanism Popula.on gene.cs studies how allele and genotype frequencies cha...
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This note was uploaded on 02/10/2014 for the course ECOL 335 taught by Professor Reinthal during the Spring '10 term at University of Arizona- Tucson.

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