Lect_6_MutationVariation

Methods that examine dna directly are more sensi6ve

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Unformatted text preview: elec6on, drin Balancing Selec6on, drin Posi6ve selec6on, drin Measuring gene6c varia6on (WITHIN a species): Before 1960s required connec6on to observable phenotype New techniques allowed to start measuring random varia6on not connected to specific phenotypes and at mul6ple loci simultaneously: Late 1960s Protein electrophoresis Late 1970s DNA varia6on (restric6on enzymes) Early 1980s DNA sequence varia6on Late 1980s DNA varia6on (microsatellites) Late 1990s DNA varia6on (genomes) How much varia6on is there in natural popula6ons? Heterozygosity (H) H = ∑ heterozygosity at each locus / total # of loci Assessing diversity: Heterozygosity at one locus using gel electrophoresis Example (1- 17 are 17 different people) 1 2 3 4 5 10 11 12 13 14 6 7 8 S F S F 15 16 17 9 Example 1 2 3 4 5 10 11 12 13 14 6 7 8 S F 15 16 17 S F Propor...
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