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Explain the order of events with special regard for

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Unformatted text preview: al product was used to make an analogue of thromboxane, a human blood clotting agent, by M. Hayashi and group, Tetrahedron Lett., 1979, 3661. Suggested solution Every step is straightforward except the final reduction where a less reactive ester must be reduced in the presence of a more reactive ketone. Protection is the answer and an acetal is suitable. OH OH O O HO Cr(VI) H2, Ni or PtO2 1. LiAlH4 OH 2. H , H2O H CO2Et CO2Et O O CO2Et CO2Et OH PROBLEM 5 How would you convert this nitro compound into the two products shown? Explain the order of events with special regard for reduction steps. H N NO2 O...
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