Explain the order of events with special regard for

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: al product was used to make an analogue of thromboxane, a human blood clotting agent, by M. Hayashi and group, Tetrahedron Lett., 1979, 3661. Suggested solution Every step is straightforward except the final reduction where a less reactive ester must be reduced in the presence of a more reactive ketone. Protection is the answer and an acetal is suitable. OH OH O O HO Cr(VI) H2, Ni or PtO2 1. LiAlH4 OH 2. H , H2O H CO2Et CO2Et O O CO2Et CO2Et OH PROBLEM 5 How would you convert this nitro compound into the two products shown? Explain the order of events with special regard for reduction steps. H N NO2 O...
View Full Document

Ask a homework question - tutors are online