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Unformatted text preview: cts shown? CHO ? HO HO CHO R ? Br R Br Purpose of the problem A simple exercise in chemoselectivity and protection. Suggested solution You would like to add an organometallic reagent to go to the right and that’s very simple as no protection is needed. A Grignard reagent will do the job. CHO HO R Mg RMgBr RBr + Et2O Br Br The other product demands more care to avoid the reactions we have just done. The aldehyde needs to be protected, as an acetal, say, before 2 Solutions Manual to accompany Organic Chemistry 2e we make the Grignard reagent from the aryl bromide. Then we can add to RCHO, and dep...
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