DNA and the Gene

This extension that serves as the unreplicated part

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Unformatted text preview: eeds to be removed, as the result of a U nitrogenous base will mutate the DNA. Another DNA polymerase is used to remove the RNA primer and simultaneously replacing them with DNA in the 5’ → 3’ direction. The gap between the strands are then closed by DNA ligase, because no matter what, DNA cannot start from a 3’ end. DNA polymerase adds only nucleotides to the free 3’ –OH on a strand. Primase synthesizes a short RNA sequence that provides the free 3’ end necessary for DNA polymerase to start working. The replisome is where it all takes place. Replication at the end for a linear chromosome: telomere. Problem: The leading strand will finish synthesizing; however the lagging strand will not because there is not enough room for primase to add a new RNA primer. This results in the lagging strand being too short after the primer is removed, and there is an unreplicated end. The unreplicated end will degrade, shortening chromosome Solution: 1) Telomeres do not contain genes that code for products needed in the cell. 2) Telmoerase, an enzyme, is involved in replicating telomeres. Catalyzes the synthesis of DNA from an RNA template. It binds...
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This note was uploaded on 02/13/2014 for the course BIO 103 taught by Professor Heidielmendorf during the Fall '10 term at Georgetown.

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