Lecture 12-Chp8-1 - Nucleotides Nucleic Acids Chp 8 Key...

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Nucleotides & Nucleic Acids – Chp. 8 Key Concept: Nucleotides are the building blocks of nucleic acids (DNA and RNA). 1
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Nucleotides 3 Key Components: Nitrogenous base Pentose sugar Ribose/deoxyribose Phosphate group Nucleosides are nucleotides without the phosphate 2 N N N N NH 2 O H OH H H H H O P - O O - O 5′ 3′
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Bases 3 HN N N H N O H 2 N NH N H O O N N N H N NH 2 N N H NH 2 O Purines Pyrimidines Adenine Guanine Thymine (DNA) Cytosine NH N H O O Uracil (RNA)
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Nomenclature 4
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Uses of Nucleotides Chemical energy Hydrolysis of ATP is coupled to biosynthesis reactions Coenzymes NAD, FAD, Acetyl- CoA Regulatory molecules Second 5
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Majority of Nucleotides in Nucleic Acids 6
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Phosphodieste r Linkage Covalent linkage through phosphate groups 5'-phosphate of one nucleotide joined to 3'-OH of another Bases are side groups on backbone Always written in 5 ' to 3 ' direction 7
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Stability of DNA and RNA DNA and RNA are prone to a slow, nonenzymatic hydrolysis of the backbone RNA is readily hydrolyzed under basic conditions 8
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What Determines Structure?
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