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Unformatted text preview: March 3, 2006 Lecture 59: Differentiation I The Cascade of Transcription Regulators Model Organisms for Genetic Differentiation Fruit fly, mice, zebrafish, plant, worm The Concept of Genomic Equivalence Do all cells contain the genetic material necessary to make any other cell, or is it list during specialization? So is it totipotent? Pluripotent? Briggs and King Experiment Removed the nucleus from a frog egg Took nucleus froeggm partially developed embryo and inserted it into embryo? The younger the donor, the higher the success rate. They found that even adult cells were totipotent Other Supporting Evidence Karyotype is constant Amount of DNA is constant FC Stewart - Mature phloem cells from carrots are totipotent. Ian Wilmut - Dolly the Sheep What Is the Fate of a Given cell? What determines it?...
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- Fall '07