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06BIS101S2013DomRecLect6

Lrodriguez 2 this lecture one gene one enzyme

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Unformatted text preview: 13 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 2 This Lecture ­One Gene-One Enzyme Hypothesis ­Inborn Errors of Metabolism. ­Molecular Basis of Dominant and Recessive Molecular Traits. Traits. ­Complete, Incomplete and Co-Dominance ­ABO Blood Groups ­Rh Disease 02/12/14 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 3 One Gene:One Enzyme Hypothesis ­ Once it had been established that genes were Once located on chromosomes, a mechanism for how genes produce the phenotype needed to be established. established. ­ The link between genotype and phenotype was first The formally proposed by George Beadle and Ed Tatum in 1941 as the “One Gene — One Enzyme One Hypothesis. Hypothesis ­ Beadle and Tatum used Beadle auxotrophs and prototrophs auxotrophs prototrophs of the bread mold Neurospora crassa. Neurospora 02/12/14 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 4 One Gene — One Enzyme Hypothesis Gene 1 Gene 2 Gene 3 Enzyme 1 Enzyme 2 Enzyme 3 Precursor P Intermediate Q Intermediate R Product S (S can be any compound that produces a discernible phenotype such as eye or skin color, flower color or black urine) ­ “The synthesis or degradation of any substrate proceeds as a stepwise The sequence of...
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