Unformatted text preview: ntigens are sugar molecules
(fucose and N-acetylgalactosamine) that are connected to
proteins on the surface of the red blood cell.
The human immune system will recognize these antigens as
“self” and not develop antibodies to those antigens present.
Therefore… Question; where are the antigens that produced the antibodies on the O
Answer; common gut bacteria have surface sugars very similar to the A and
B blood group antigens. The immune system makes antibodies to these Ablood
like and B-like bacterial antigens.
02/12/14 BIS101001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013
BIS101001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 31 Codominance of A/B blood group antigens
In A/B/O blood groups, both the IA
and IB alleles are observed in the
heterozygote. The IA and IB alleles
code for different antigens
(glycoproteins) displayed on the
surface of the red blood cell. The
(i) allele expresses no
glycoproteins and produces the O
blood group. As can seen at the...
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- Spring '08
- R.L. Rodriguez