06BIS101S2013DomRecLect6

This paradox can be resolved by collecting more data

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Unformatted text preview: does not skip a generation q one parent is affected and about half of the progeny are affected q the sexes are equally affected ­ However, like most enzyme deficiency disorders, it is well documented that However, alkaptonuria is an autosomal recessive trait. This paradox can be resolved by collecting more data on the family. As can be seen on the right, there are two consanguineous matings in the pedigree making the pattern of inheritance consistent with an autosomal recessive trait. For rare, recessive traits, affected parents must be related in some way if they are to produce affected offspring. parents 02/12/14 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 9 Homogentisic Acid Pathway Ttr Gene Tyr transaminase tyrosine Ppo Gene p-OH-phenylpyruvate oxidase p-OH-phenylpyruvate Hgo Gene homogentisate 1,2 dioxygenase homogentisic acid maleylacetoacetate ­ AKU is an excellent example of Bead...
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