10BIS1012013EuKTranscLect10

Bis101001spring2013genesandgeneexpressionrlrodriguez

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Unformatted text preview: ukaryotic Transcription Factors ­ Basal factors bind to the promoter. q q ­ TBP – TATA box binding protein TAF – TBP associated factors RNA polymerase II binds to basal factors. BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 7 Eukaryotic Transcription Activator Proteins ­ Also called transcription factors ­ Bind to enhancer DNA in specific ways ­ Interact with other proteins to activate and increase transcription as much as 100-fold above basal levels ­ Two structural domains mediate these functions: q q ebruary 12, 2014 DNA-binding domain Transcription-activator domain BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 8 Eukaryotic Transcription Activator Proteins ­ ­ ­ ­ ebruary 12, 2014 The human body consists of about 300 different cell types organized in 4 principle tissues: Epithelial Nervous Connective Muscle Every cell in the body contains the same genes Not every cell expresses all the genes at once T...
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