10BIS1012013EuKTranscLect10

Lrodriguez 2013

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Unformatted text preview: riguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 11 Eukaryotic Transcription Complex ­ A functional transcription complex consists of many factors ­ Factors include: Activators Repressors Coactivators Basal factors Non-coding RNAs BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 12 Formation of Active Eukaryotic Initiation Complex ­ ­ ­ ­ ­ ­ The diagram at the right shows the The complexes formed on the TATA box by the transcription factors and RNA polymerase II (RNAPII) (A) The TBP complex’s with TFIID to (A) bind to the TATA box. (B) TFIID is stabilized by TFIIA and TFIIB (B) and binds to the TATA box. (C) TFIIE and TFIIH join the complex on (C) the TATA box with RNAPII with TFIIF and other factors. (D) RNAPII is positioned by TFIIB, and (D) its carboxy-terminal domain (CTD) is bound by TFIID. (E) The CTD is phosphorylated by TFIIH (E) and is released by TFIID. The RNAPII is now competent to tr...
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This note was uploaded on 02/12/2014 for the course BIS 101 taught by Professor Simonchan during the Spring '08 term at UC Davis.

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