10BIS1012013EuKTranscLect10

Lrodriguez 2013

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Unformatted text preview: ng 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 2 This Lecture: Key Concepts ­ ­ ­ ­ ­ In eukaryotes, the initial RNA transcript (heterogeneous In nuclear RNA — hnRNA or pre-mRNA) iis processed in s hnRNA several way to generate the final mRNA. several hnRNA must be enzymatically “capped” and “tailed” after hnRNA after transcription. transcription. Many eukaryotic genes contain intervening DNA sequences Many called “introns” that must be spliced out of the that corresponding hnRNA before translation. corresponding hnRNA can be spliced in several ways. One method hnRNA requires the action of an RNA-containing enzyme called a spliceosome. spliceosome. Alternate splicing of hnRNA can produce two functional proteins from the same mRNA. BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 3 Differences Between Prokaryotic/Eukar...
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