10BIS1012013EuKTranscLect10

Lrodriguez 2013

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Unformatted text preview: ent in 105 to 106 present copies/cell. BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 32 Spliceosome Detail Intron 1 E A Ex 1 on U2 2 on x AG-3’ 5’-GU U1 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 33 Steps in the Intron Splicing U1 binds to 5' end of the intron splice of site site U4-U5-U6 complex binds to 5' end of the intron splice site U1 and U4 are displaced U6 binds to U2 5'-splice site to 5'-splice branch point A branch U2 binds to branch point recognition sequence U5 binds exon sequences Intron is removed RNA Splicing Video BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 34 EM of Spliceosome BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gen...
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