10BIS1012013EuKTranscLect10

Lrodriguez 2013

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Unformatted text preview: ranscription is programed to be cell and tissue specific Enhancers are DNA sequence that work through transcription activators and coactivators to provide cell or tissuespecific transcription BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 9 Enhancers: Tissue-Specific Gene Expression ­Enhancers act at a distance to enhance transcription efficiency. Enhancers Enhancers have 4 important features: ­They can contain repeated DNA sequences that are not part of the They promoter itself. promoter ­They can act over a considerable distance, 50 to 5000 bp. ­They can act in either orientation. ­They can act at either the 5' or 3' side of the gene. ­Enhancers can work only in those tissues that produce a DNA binding Enhancers protein specific to the enhancer. protein BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 10 Eukaryotic Enhancers ­ Tissue specific transcriptional activators bind to specific enhancers at specific times to increase transcriptional levels. BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rod...
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