10BIS1012013EuKTranscLect10

Exonintron these rnas range in size these from 115

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Unformatted text preview: ht, the phosphate on the As G at the 5’ end of intron 1 forms a bond with at end the 2'OH of the branch point A. The 3'OH on the end of Exon 1 attacks the The 5' end of Exon 2, to form a phosphodiester bond. The structure of the released intron is referred to as a lariat. lariat This occurs inside the nucleus and about 2 This to 30 minutes after the transcript is initiated. to A BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez A A 31 Spliceosome is a small ribonucleoprotein (Snurp) ­ ­ ­ ­ The spliceosome is a special The RNA-containing enzyme called a small ribonucleoprotein or “Snurp”. The spliceosome contains The several small RNAs (U1, U2, U4, U5 and U6). U4, These RNA molecules These contain sequences complementary to the conserved sequences in the exon/intron junction. exon/intron These RNAs range in size These from 115 bases to 189 bases in mammals and 110 to 1175 in yeast. Some snRNAs are very rare while others may be pres...
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