10BIS1012013EuKTranscLect10

Nucleotides the signal in the 3 utr of eukaryotic

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Unformatted text preview: uez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 20 Capping Reaction Summary BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 21 Tailing of Eukaryotic mRNA ­ ­ ­ ­ Most eukaryotic mRNAs have a special "tail" added to the 3' Most end. This tail is added by a special processing event that recognizes sequence elements in the 3' untranslated region (3' UTR) of eukaryotic mRNA and replaces the true 3' end of of the transcript with a tail consisting of 20-250 adenine nucleotides. nucleotides. The signal in the 3' UTR of eukaryotic mRNA that triggers The tailing is the highly conserved sequence, AAUAAA (5'A98 A91 AAUAAA U100 A99 A983’). A complex consisting of 4 proteins assembles at this sequence complex to carry out the processing. The protein CPSF is a small CPSF nuclear ribonucleoprotein or "snurp" that contains a small nuclear that RNA molecule (about 100...
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This note was uploaded on 02/12/2014 for the course BIS 101 taught by Professor Simonchan during the Spring '08 term at UC Davis.

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