10BIS1012013EuKTranscLect10

Process splicing of introns in nuclear genes takes

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Unformatted text preview: s (splice junctions), phosphodiester ), followed by phosphodiester bond formation between the ends of the exons. This can occur as one coordinated transfer reaction or as a sequence of reactions. Although the breaking of phosphodiester bonds is a common occurrence Although in the cell, the formation of phosphodiester bonds between two fragments of RNA is unique to the RNA splicing process. RNA splicing can be divided into two principal mechanisms: autocatalytic RNA and spliceosome-mediated removal of introns from nuclear gene transcripts (hnRNAs or preRNA). transcripts BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 30 Spliceosome removal of introns ­ ­ ­ ­ ­ Spliceosomes assemble in a stepwise Spliceosomes process on the hnRNA prior to splicing. process Splicing of introns in nuclear genes takes Splicing place by transesterification (the transesterification simultaneous cleavage and formation of a phosphodiester bond). As shown at the rig...
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