This preview shows page 1. Sign up to view the full content.
Unformatted text preview: ez 29 Wobble Hypothesis and Wobble Rules
Because there are 61 codons for 20 amino acids, one could
reason that there must be 61 tRNA. In reality, there are fewer
tRNAs than codons. This means that one tRNA must
possess the ability to recognize more than one codon.
This explanation was first proposed by Francis Crick as the
Wobble Hypothesis, which states that because of the unusual
physico-chemical environment in the anticodon loop of the
tRNA, the 3rd base toward the 5' side of the loop can
temporarily form hydrogen bonds with other bases. This
enables one tRNA to interact with synonymous codons that
differ at the third position. (e.g. UUU and UUC = phe).
According to the Wobble (base pairing) Rules, the 3rd base
toward the 5' end of the anticodon loop can hydrogen bond
with certain bases in the 3rd position of the codon:
BIS101001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013
BIS101001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 30...
View Full Document
This note was uploaded on 02/12/2014 for the course BIS 101 taught by Professor Simonchan during the Spring '08 term at UC Davis.
- Spring '08