Lrodriguez 2013

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Unformatted text preview: ez 29 Wobble Hypothesis and Wobble Rules ­ ­ ­ Because there are 61 codons for 20 amino acids, one could Because reason that there must be 61 tRNA. In reality, there are fewer tRNAs than codons. This means that one tRNA must possess the ability to recognize more than one codon. This explanation was first proposed by Francis Crick as the This Wobble Hypothesis, which states that because of the unusual physico-chemical environment in the anticodon loop of the tRNA, the 3rd base toward the 5' side of the loop can 3rd temporarily form hydrogen bonds with other bases. This enables one tRNA to interact with synonymous codons that synonymous differ at the third position. (e.g. UUU and UUC = phe). According to the Wobble (base pairing) Rules, the 3rd base According toward the 5' end of the anticodon loop can hydrogen bond with certain bases in the 3rd position of the codon: with BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 30...
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This note was uploaded on 02/12/2014 for the course BIS 101 taught by Professor Simonchan during the Spring '08 term at UC Davis.

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