12BIS1012013TranslatLect12

Lrodriguez 2013

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Unformatted text preview: Wobble in the Anticodon Loop BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 31 Wobble Base Pairing Rules Wobble Base at 5' end of Anticodon I (deaminated A) G U C A Base at 3' end of Codon U, A, C C, U A, G G U BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 32 Isoaccepting tRNA ­ Using the six codons for serine, we can demonstrate how the Using wobble rule can reduce the number of tRNAs necessary to recognize synonymous codons: recognize Codon # Codon Anticodon Anticodon ­ ­ 1 5'UCU 3'AGA 3''AGI 3 2 UCC AGG 3 UCA AGU AGU 4 UCG AGC 5 AGC UCG UCG 6 AGU UCA Using the Wobble Rules, a minimum of 32 anticodons can Using accommodate the 61 codons. accommodate tRNAs that recognize more than one codon are called tRNAs isoaccepting tRNAs. isoaccepting BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013...
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This note was uploaded on 02/12/2014 for the course BIS 101 taught by Professor Simonchan during the Spring '08 term at UC Davis.

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