12BIS1012013TranslatLect12

Lrodriguez 28 charging the trna with aminoacyl

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Unformatted text preview: ­ mRNA (codons) ­ Ribosomes ­ Transfer RNA (tRNA) ­ Aminoacyl synthetase ­ Amino acids ­ Initiation, elongation and termination Initiation, factors factors ­ ATP, GTP BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 26 Modified Bases in tRNA ­ The nitrogenous bases in tRNAs are highly modified. This The gives each tRNA a unique “signature.” These unique signatures permit each tRNA to recognize (or be recognized by) its cognate (corresponding) aminoacyl synthetase enzymes. enzymes. BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 27 Modifications of Specific tRNAs BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez 28 Charging the tRNA with Aminoacyl Synthetase* Purves et al, 1997, Life the Purves Science of Biology W.H. Freeman Science BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodriguez ©2013 BIS101­001, Spring 2013—Genes and Gene Expression, R.L. Rodrigu...
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